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310-268-8466

2001 S. Barrington Avenue, Suite 208 Los Angeles, CA 90025

Selected Research on Nicotinamide Adenine Dinucleotide (NAD+)

Aman Y, Qiu Y, Tao J, Fang EF. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Transl Med Aging. 2018 Jan;2(1):30-37. doi: 10.1016/j.tma.2018.08.003

Bonkowski MS, Sinclair DA. Slowing ageing by design: The Rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. doi: 10.1038/nrm.2016.93

Braidy N, Liu Y. NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis. Exp Gerontol. 2020 Apr;132:110831. doi: 10.1016/j.exger.2020.110831

Csiszar A, Tarantini S, Yabluchanskiy A, et al. Role of endothelial NAD+ deficiency in age-related vascular dysfunction. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1253-H1266. doi: 10.1152/ajpheart.00039.2019

Custodero C, Saini SK, Shin MJ, et al. Nicotinamide riboside – A missing piece in the puzzle of exercise therapy for older adults? Exp Gerontol. 2020;137:110972. doi: 10.1016/j.exger.2020.110972

Frederick DW, Loro E, Liu L, et al. Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle. Cell Metabolism. 2016;24(2):269-282. doi: 10.1016/j.cmet.2016.07.005

Kane AE, Sinclair DA. Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases. Circ Res. 2018;123(7):868-885. doi: doi/10.1161/CIRCRESAHA.118.312498

Lin S, Guarente L. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol. 2003 Apr;15(2):241-246. doi: 10.1093/ajcn/nqaa072

Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9:1286. doi: 10.1038/s41467-018-03421-7

Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020 Aug;112(2):413-426. doi: 10.1093/ajcn/nqaa072

Rutherford L, Gadol E, Broom SL, Olds T, Mestayer RF, Mestayer P. Intravenous administration of nicotinamide adenine dinucleotide alleviates tremors associated with Parkinson’s disease: A case report. J Gerontol Geriatr Med. 2020;6:046. doi: 10.24966/GGM-8662/100046

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